Modern methods of synthesis and reactions of Carbonyl compounds, addition of N, O, and S nuclophiles, Reduction using hydride reagents, chemo and stereoselctivity, formation of enols and enamines, kinetic and thermodynamic enolates, lithium and boron enolates in aldol and Michael reactions, stereoselective aldol condensations, alkylation and acylation of enolates, condensation reactions, Claisen, Dieckman, Knoevenegal, Stobbe and Darzen glycidic ester, acyloin, emphasis on synthetic utility of these reactions, Rearrangement reactions involving electron deficient carbon, nitrogen, oxygen centers and the synthetic utility of these rearrangements. Coupling reactions: Heck, Suzuki, Negishi, Stille, Sonogashira coupling Heterocyclic chemistry: Chemistry of furan, pyrrole, pyridine, indole, quioline, isoquinoline, azoles, pyrimidine and purine: Chemistry of mono and disaccharides. Pericyclic reactions: Classification, electrocyclic, sigmatropic, cycloaddition, chelotropic and ene reactions, Woodward-Hoffmann rules, frontier orbital and orbital symmetry correlation approaches, examples highlighting pericyclic reactions in organic synthesis, stereochemical aspects. Natural Product synthesis: concept of retro synthetic analysis with applications.
Text/ Reference Books:
- Clayden, Greeves, Warren & Wothers Organic Chemistry, Oxford University.
- Carey F. A. and Sundberg R. J. Advanced Organic Chemistry, Part A and Part B, Springer.
- Norman R. O. C. and Coxon J. M. Principles of Organic Synthesis, Nelson Thornes.
- Joule J. A. and Mills K. Heterocyclic Chemistry, Wiley-blackwell.
- Warren S. Organic Synthesis: The Disconnection Approach, Wiley Student Ed.
- Woodward R. B. and Hoffmann R. The Conservation of Orbital Symmetry,
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