Subject Code: CY7L013	Subject Name: Methods in Organic Synthesis	L-T-P: 3-0-0	Credit: 3
Prerequisite(s): Nil
A review of various synthetic methods in organic chemistry: Formation of C-C, C=C, C C bonds and various rings (namely 3, 4, 5, 6, 7 and 8-membered ring); disconnection approach, chemoselective synthesis, Selected syntheses of natural and unnatural products having these ring systems. A concise introduction to various aspects of asymmetric synthesis followed by detailed discussion on resolution, chiral auxiliaries, chiral ligands, chiral catalysts, and organocatalysts with specific examples. A brief discussion on biosynthesis and biomimetic synthesis with selected examples from monoterpenes, sesquiterpenes, diterpenes, steroids, and alkaloids. Introduction of domino and tandem reaction concepts with a detailed discussion, Protecting groups: protection of hydroxyl, carboxyl, carbonyl, amino groups. Protection of carbon-carbon multiple bonds. Illustration of protection and deprotection in synthesis.
Text/ Reference Books: Warren S. Organic Synthesis: The Disconnection Approach, Wiley. Smith M. B. and March J. March’s Advanced Organic Chemistry, Wiley. Carey F. A. and Sundberg R. Advanced Organic Chemistry, Part B, Plenum Press. Trost B. M. and Fleming I. Comprehensive Organic Synthesis, Pergamon Press. Norman R. O. C. and Coxon J. M. Principles of Organic Synthesis, Nelson Thornes.