Subject Code: CY7L035	Subject Name: Advanced Topics in Organic Chemistry	L-T-P: 3-0-0	Credit: 3
Prerequisite(s): Nil
Principles of asymmetric synthesis: Introduction, Topocity in molecules Homotopic, stereoheterotopic (enantiotopic and diastereotopic) groups and facessymmetry, substitution and addition criteria. Prochirality nomenclature: Pro-R, Pro-S, Re and Si. Selectivity in synthesis:Stereo specific reactions (substrate stereoselectivity). Stereo selective reactions (product stereoselectivity): Enantioselectivity and diastereoselectivity. Conditions for stereoselectivity: Symmetry and transition state criteria, kinetic and thermodynamic control. Methods for inducing enantio and diastereoselectivity. Methodology of asymmetric synthesis: Classification of asymmetric reactions into substrate controlled, chiral auxiliary controlled, chiral reagent controlled and chiral catalyst controlled.Total Synthesis of Biological Active Compounds.
Text/ Reference Books: Nasipuri D. Stereochemistry of Organic Compounds, New Age Publications. Carruthers W. Modern Methods of Organic Synthesis, Cambridge University Press. Gawley R. E. and Aube J. Principles of Asymmetric Synthesis, Pergamon. Eliel E. L. Stereochemistry of Organic Compounds, Wiley.