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IITBBS

Personal Profile of Dr. Soumendra Rana

Photo of Soumendra Rana
Dr. Soumendra Rana
Title : Assistant Professor
School : Basic Sciences
Office (Room No.) : 314, School of Basic Sciences
Phone No. (Office) : +91-674-7135154 (Office); +91-674-7135354 (Lab)
Email : soumendra@iitbbs.ac.in
Research Scholars : Ph.D. (1 graduated; 4 continuing), M.Sc. (2 graduated)
Courses Taught
Chemistry (CY1L001); Receptor Pharmacology & Drug Discovery (CY7L020); Chemical Biology of Receptors (CY7L016); Structure Function of Biomolecules (CY7L019); Biochemistry (CY7L001); Biosciences (CYA2001); Introduction to Biosciences & Technology (ID2L001); Computational Methods & Application (CY5L009); Advanced Instrumentation Lab (CY5P004); Organic Chemistry Lab (CY5P001); Physical Methods in Inorganic Chemistry (CY7L006); B. Tech Chemistry Lab (CY1P001)
Research Interests
G-protein Coupled Receptors; Signal Transduction; Molecular Modeling and Computational Biology; Chemical & Cellular Biology; Protein-Protein Interactions; Protein Design and Engineering; Drug Design and Discovery
Degree Discipline Year School
Ph.D. Molecular Biophysics 2007 Indian Institute of Technology Bombay
Recent Publications (International Journals)
Mishra, R.; Das, A.; Rana, S. "Resveratrol Binding to Human Complement fragment 5a (hC5a) may Modulate the C5aR Signaling". 2019 (Submitted)
Mishra, R.; Rana, S. "A Rational Search for Discovering Potential Neutraligands of Human Complement fragment 5a (hC5a)." Bioorg. Med. Chem. 2019, 27, 115052
Sahoo, A.; Mishra, R.; Rana, S. "The Model Structures of the Complement Component 5a Receptor (C5aR) Bound to the Native and Engineered hC5a." Sci. Rep. 2018, 8, 2955.
Rana, S.; Sahoo, A.; Majhi, B. "Structural Complexes of Agonist, Inverse Agonist and Antagonist Bound C5a Receptor: Insights into Pharmacology and Signaling." Mol. BioSyst. 2016, 12, 1586-1599.
Rana, S.; Sahoo, A.; Majhi, B. "Allosterism in human Complement Component 5a (hC5a): A Damper of C5a Receptor (C5aR) Signaling." J. Bimol. Struct. Dyn. 2015, 1-13.
Rana, S.; Sahoo, A. "Model structures of inactive and peptide agonist bound C5aR: Insights into agonist binding, selectivity and activation." Biochem. Biophy. Rep. 2015, 1, 85-96.
Rana, S.; Yang, L; Hassanian, S. M.; Rezaie A. R. "Determinants of the Specificity of Protease-activated Receptors-1 and 2 Signaling by Factor Xa and Thrombin." J. Cell. Biochem. 2012, 113, 977-84.
Akiri, K.; Cherukuvada, S.; Rana, S.; Nangia, A."Crystal Structures of Pyridine Sulfonamides and Sulfonic Acids." Cryst. Growth Des. 2012, 12, 4567-73.
Rana, S.; Baranski, T. J. "Third Extracellular Loop (EC3)-N terminus Interaction is Important for 7TM Receptor Function: Implication for an Activation 'Microswitch' Switch Region." J. Biol. Chem. 2010, 285, 31472-83.
Rana, S.; Kundu, B.; Durani, S. "A Double Catgrip Mixed L and D Mini Protein Only 20 Residues Long." Bioorg. Med. Chem. 2007, 15, 3874-3882.
Rana, S.; Kundu, B.; Durani, S. "A Synthetic Cholinergic Receptor of Mixed-L, D Residues Exceptionally Small and Simple." Biopolymers 2007, 87, 231-243.
Joshi, S.; Rana, S.; Wangikar, P.; Durani, S. "Computational Design of Proteins Stereochemically Optimized in Size, Stability and Folding Speed". Biopolymers 2006, 83, 122-134. (Designed THBs were Featured on the Cover Page of Biopolymers).
Rana, S.; Kundu, B.; Durani, S. "A Small Peptide Stereochemically Customized as a Globular Fold with a Molecular Cleft". Chemical Communications 2005, 11, 207-209. (Featured as Hot article by Royal Society of Chemistry and as news in Chem. Sci. and Chemistry World, Dec 26, 2004)
Rana, S.; Kundu, B.; Durani, S. "Stereospecific Peptide Folds. A Rationally Designed Molecular Bracelet." Chemical Communications 2004, 21, 2462-2463.
Academic Honors & Awards
  • Member of the International Chemical Biology Society
  • Life Member of Society of Biological Chemists, India
  • Life Member of Indian Peptide Society
  • Life Member of American Peptide Society
Professional Experience
Post doctoral : Washington University School of Medicine in St. Louis; St. Louis University School of Medicine; University of Arizona, Tucson
Projects

Structural Studies on the Interaction of hC5a with the N-terminus Peptides of C5aR and C5L2 Receptor (2017-2020)

Sponsoring Agency-DST, New Delhi, India

 

Structure-Function studies of Extra Cellular Loop 2 (ECL2) of C5aR and C5L2 receptors (2013-2015)

Sponsoring Agency-IIT Bhubaneswar, India