Dr. Ashis Biswas

Associate Professor

School of Basic Sciences

Office : Room 320, School of Basic Sciences, Arugul campus

Phone : 06747135118

Email : abiswas@iitbbs.ac.in

Education

Degree	Discipline	Year	School
Ph.D.	Biophysical Chemistry	2006	Bose Institute (Jadavpur University)

Research Interests

Biophysical Chemistry, Protein Chemistry & Spectroscopy, DNA Binding and Photo and Chemical Nuclease Activity of Co-ordination Complexes, Structure-Function Elucidation of Various Small Heat Shock Proteins Related to Different Diseases (Cataract, Leprosy and Tuberculosis). For detailed information refer to the research group website.

Teaching

B. Tech. level - Chemistry Theory (CY1L001), Chemistry Laboratory (CY1P001), Introduction to Bioscience and Technology (ID2L002). M.Sc. Level - Thermodynamics and Chemical Equilibrium (CY5L005), Physical Chemistry Laboratory (CY5P003), Biophysical Chemistry (CY7L021).

Publications

Journals

1Sayed Muktar Hossain, Avinash Lakma, Rabindra Nath Pradhan, Ayon Chakraborty, Ashis Biswas and Akhilesh Kumar Singh - “Synthesis and characterization of a novel, ditopic, reversible and highly selective, “Turn-On” fluorescent chemosensor for Al3+ ion”, RSC Advances, 5, 63338-63344 (2015).

2Alok Kumar Panda, Sandip Kumar Nandi, Ayon Chakraborty, Ram H. Nagaraj and Ashis Biswas - “Differential role of arginine mutations on the structure and functions of alpha-crystallin”, Biochim Biophys Acta. (2015). doi: 10.1016/j.bbagen.2015.06.004.

3Ashis Biswas, Srabani Karmakar, Aritra Chowdhury and K. P. Das - “Interaction of α-Crystallin with Some Small Molecules and its effect on its structure function”, Biochim Biophys Acta. (2015). doi: 10.1016/j.bbagen.2015.06.002.

4Subhashree P. Dash, Alok Kumar Panda, Sagarika Pasayat, Rupam Dinda, Ashis Biswas, Edward R. T. Tiekink, Subhadip Mukhopadhyay, Sujit K. Bhutia, Werner Kaminsky and Ekkehard Sinn - “Oxidovanadium(V) complexes of aroylhydrazones incorporating heterocycles: Synthesis, characterization and study of DNA binding, photo-induced DNA cleavage and cytotoxic activities”, RSC Advances, 5, 51852 – 51867 (2015).

5Sandip Kumar Nandi, Alok Kumar Panda, Ayon Chakraborty, Sougata Sinha Ray and Ashis Biswas - “Role of Subunit Exchange and Electrostatic Interactions on the Chaperone Activity of Mycobacterium leprae HSP18”, PLoS One, 10(6), e0129734 (2015).

6Sandip Kumar Nandi, Ayon Chakraborty, Alok Kumar Panda, Sougata Sinha Ray, Rajiv Kumar Kar, Anirban Bhunia and Ashis Biswas - “Interaction of ATP with a small heat shock protein from Mycobacterium leprae: effect on its structure and function”, PLoS Negl Trop Dis, 9(3), e0003661 (2015).

7Saswati, Ayon Chakraborty, Subhashree P. Dash, Alok Kumar Panda, Rama Acharyya, Ashis Biswas, Subhadip Mukhopadhyay, Sujit K Bhutia, Aurelien Crochet, Yogesh P. Patil, Munirathinam Nethaji and Rupam Dinda - “Synthesis, X-ray structure and in vitro cytotoxicity studies of Cu(I/II) complexes of thiosemicarbazone: special emphasis on their interactions with DNA”, Dalton Trans, 44(13), 6140-6157 (2015).

8Subhashree P. Dash, Alok Kumar Panda, Sagarika Pasayat, Sudarshana Majumder, Ashis Biswas, Werner Kaminsky, Subhadip Mukhopadhyay, Sujit K. Bhutia and Rupam Dinda - “Evaluation of the cell cytotoxicity and DNA/BSA binding and cleavage activity of some dioxidovanadium(V) complexes containing aroylhydrazones”, J Inorg Biochem, 144, 1-12 (2015).

9Michael A. DiMauro, , Sandip Kumar Nandi, Cibin T. Raghavan, Rajiv Kumar Kar, Benlian Wang, Anirban Bhunia, Ram H. Nagaraj and Ashis Biswas - “Acetylation of Gly1 and Lys2 promotes aggregation of human gammaD-crystallin”, Biochemistry ,53(46), 7269-7282 (2014).

10Subhashree. P. Dash, Alok Kumar Panda, Sagarika Pasayat, Rupam Dinda, Ashis Biswas, E. R. Tiekink, Yogesh P. Patil, M. Nethaji, Werner Kaminsky, Subhadip Mukhopadhyay and Sujit K. Bhutia - “Syntheses and structural investigation of some alkali metal ion-mediated LV(V)O2(-) (L(2-) = tridentate ONO ligands) species: DNA binding, photo-induced DNA cleavage and cytotoxic activities”, Dalton Trans, 43(26), 10139-10156 (2014).

11Sandip Kumar Nandi, Elengikal A. A. Rehna, Alok Kumar Panda, Sugathan Shiburaj, Kuppamuthu Dharmalingam and Ashis Biswas – “A S52P mutation in the 'α-crystallin domain' of Mycobacterium leprae HSP18 reduces its oligomeric size and chaperone function”, FEBS J, 280(23), 5994-6009(2013).

12Rooban B. Nahomi, Rong Huang, Sandip Kumar Nandi, Benlian Wang, Smitha Padmanabha, Puttur Santhoshkumar, Slawomir Filipek, Ashis Biswas and Ram H. Nagaraj – “Acetylation of lysine 92 improves the chaperone and anti-apoptotic activities of human alphaB-crystallin”, Biochemistry, 52(45), 8126-38 (2013).

13Ram H. Nagaraj, Alok Kumar Panda, Shilpa Shanthakumar, Puttur Santhoshkumar, NagaRekha Pasupuleti, Benlian Wang and Ashis Biswas - “Hydroimidazolone modification of the conserved Arg12 in small heat shock proteins: studies on the structure and chaperone function using mutant mimics”, PLoS One, 7, e30257 (2012).

14Ram H. Nagaraj, Rooban B. Nahomi, Shilpa Shanthakumar, Mikhail Linetsky, Smitha Padmanabha, Nagarekha Pasupuleti, Benlian Wang, Puttur Santhoshkumar, Alok Kumar Panda and Ashis Biswas - “Acetylation of alphaA-crystallin in the human lens: effects on structure and chaperone function”, Biochim. Biophys. Acta, 1822, 120-129 (2012).

15Zhi-Qiang Wang, Jesús Tejero, Chin-Chuan Wei, Mohammad Mahfuzul Haque, Jerome Santolini, Mohammed Fadlalla, Ashis Biswas and Dennis J. Stuehr - “Arg375 tunes tetrahydrobiopterin functions and modulates catalysis by inducible nitric oxide synthase”, J Inorg. Biochem., 108, 203-215 (2012).

16Ashis Biswas, Srabani Karmakar, Victor Banerjee, Sudipa Saha, Madhuchhanda Kundu, Jaya Bhattacharyya, Dipak Chandra Konar and K. P. Das- “Biophysical studies on the molecular chaperone function, structure and interaction of eye lens protein a-crystallin – A Review”, J Indian Chem. Soc., 88, 1827-1855 (2011).

17Jesús Tejero, Ashis Biswas, Mohammad Mahfuzul Haque, Zhi‑Qiang Wang, Craig Hemann, Cornelius L. Varnado, Zachary Novince, Russ Hille, Douglas C. Goodwin and Dennis J. Stuehr- “Mesohaem substitution reveals how haem electronic properties can influence the kinetic and catalytic parameters of neuronal NO synthase”, Biochem. J., 433, 163 - 174 (2011).

18Syed Mohsin Waheed, Arnab Ghosh, Ritu Chakravarti, Ashis Biswas, Mohammad Mahfuzul Haque, Koustubh Panda and Dennis J. Stuehr- “Nitric oxide blocks cellular heme insertion into a broad range of heme proteins”, Free Radic. Biol. Med., 48, 1548 – 1558 (2010).

19Monolekha Bhattacharya. Ashis Biswas and Amit Kumar Das - “Interaction analysis of TcrX/Y two component system from Mycobacterium tuberculosis”, Biochemie, 92, 263 – 272 (2010).

20Jesús Tejero, Ashis Biswas, Zhi-Qiang Wang, Richard C. Page, Mohammad Mahfuzul Haque, Craig Hemann, Jay L. Zweier, Saurav Misra and Dennis J. Stuehr - “Stabilization and Characterization of a Heme-Oxy Reaction Intermediate in Inducible Nitric Oxide Synthase”, J Biol. Chem., 283, 33498 - 33507 (2008).

Academic Honors & Awards

National Scholarship (1991): For holding 101st position in Secondary Examination
National Scholarship (1993): For holding 81st position in Higher Secondary
American Heart Association (AHA) Postdoctoral Fellowship Award (2008-2010): Principal Investigator, $88,000 for two years

01 (Degree awarded), 01 (Submitted), 03 (Continuing).

Projects

Role of C-terminal Region of Mycobacterium Tuberculosis Hsp16.3 for its Structure, Stability and Chaperon Function-A Biophysical and Site Directed Truncation Study
Ongoing Sponsoring Agency - CSIR, Government of India.
Catalytic activity of endothelial nitric oxide synthase – a probe into the molecular basis of its electron transfer limitation - 2010 – 2013
Sponsoring Agency - Department of Science and Technology, New Delhi, India.
Structural basis enhancement of chaperone function of alpha-crystallin - 2010 – 2012
Sponsoring Agency – IIT Bhubaneswar, India.

For further information please refer to the research group website.