Dr. Anasuya RoychowdhuryAssistant Professor
School of Basic Sciences

Research Interests

  • Oncogenic mechanisms of gastrointestinal (Stomach/gastric, pancreatic, colorectal) cancers 
  • Cancer and gut microbiome
  • Cancer therapeutics
  • Cancer biomarkers

Contact Details

  • SBS-315
  • 674-713-5106
  • aroychowdhury@iitbbs.ac.in

Other Profile Link(s)

Education

 Degree Discipline Year School
 Ph.D. Biochemistry and Molecular Biology 2009 University Of Texas Medical Branch at Galveston, Texas, USA
 

Biosketch

 

Teaching

Undergraduate (B.Tech.) Courses: 
  • An Introduction to Bioscience & Technology [BS2L001]:  B.Tech. 2nd year course (2-0-0)
  • Chemistry Laboratory [CY5S001]: B.Tech. First year course (0-0-3)
Post-graduate (M.Sc./Ph.D.) Courses:  
  • Chemistry of Pharmaceutics [CY7L030]: Joint M. Sc. Chemistry/Ph.D. course (3-0-0)
  • Biochemistry [CY7L001]: Joint M. Sc. Chemistry/Ph.D. course (3-0-0)
  • Thermodynamics and Chemical Equilibrium [CY5L005]: M.Sc. Chemistry (3-1-0)
  • Literature survey & seminar I [CY5S001]: M.Sc. Chemistry (0-0-3)
  • Advanced Instrumentation Laboratory [CY5P004]: M.Sc. Chemistry (0-0-6)
  • Physical Chemistry Laboratory [CY5L003]: M.Sc. Chemistry (0-0-6) 
 

Projects

  • Extramural Ad-Hoc Grant (2020-23) entitled “Identification, synthesis and validation of potential ATAD2 ligands as a therapeutic strategy for stomach cancer”. Sponsoring Agency: ICMR, India. Role: PI (ongoing).
  • R&D grant (2020-23) entitled “Functional Consequences of Cancer Testis Antigen ATAD2 in Pancreatic Cancer”. Sponsoring Agency: DBT, India. Role: PI (ongoing).
  • Vanderbilt International Research Grant (2015-17) entitled “The Role of Clock ATPase KaiC in the Temporal Control of DNA Replication” Sponsoring Agency: Vanderbilt International Research Grants Program, Vanderbilt University, USA. Role: PI (completed).
  • Seed Money Project (2014-16) entitled “Chemo-mechanistic Physiology and Regulation of KaiC ATPase”. Sponsoring Agency: IIT Bhubaneswar; Role: PI (completed).
  • Indo-US Joint Centre (2014-2017) on “Nanostructure Genomics: Designing Functionality of 2-Dimensional Nanostructures and Nano-Bio Interfaces”. Sponsoring Agency: The Indo-US Science and Technology Forum (IUSSTF); Role: co-PI (completed).
 
 

Recent Publications (International Journals)

1Effects of Probiotics at the Interface of Metabolism and Immunity to Prevent Colorectal Cancer-Related Gut-inflammation: A Systematic Network and Meta-analysis with Molecular Docking Studies, S. Patra, N. Sahu, S. Saxena, B. Pradhan, S. K. Nayak, A. Roychowdhury, Front Microbiol. 2022 May 27;13:878297. doi: 10.3389/fmicb.2022.878297 [I.F=5.64].
2MicroRNA-217 Modulates Pancreatic Cancer Progression via Targeting ATAD2. M. Dutta, B. Das, D. Mohapatra, P Behera, S Senapati, A. Roychowdhury, Life Sci. 2022 Jul 15;301:120592. doi: 10.1016/j.lfs.2022.120592. [I.F=5.037].
3Emerging oncogene ATAD2: Signaling cascades and therapeutic initiatives. A Nayak, M Dutta, A Roychowdhury, Life Sci. 2021 Jul 1;276:119322. doi: 10.1016/j.lfs.2021.119322 [I.F=5.037].
4Systematic network and meta-analysis on the antiviral mechanisms of probiotics: a preventive and treatment strategy to mitigate SARS-CoV-2 infection. S Patra, S Saxena, N Sahu, B Pradhan, A Roychowdhury, Probiotics and antimicrobial proteins, 2021 Aug;13(4):1138-1156. doi: 10.1007/s12602-021-09748-w [I.F=4.609].
5Oncogenic potential of ATAD2 in stomach cancer and insights into the protein-protein interactions at its AAA+ ATPase domain and bromodomain. A Nayak, S Kumar, SP Singh, A Bhattacharyya, A Dixit, A Roychowdhury. J Biomol Struct Dyn. 2021 Jan 13:1-17. doi: 10.1080/07391102.2021.1871959 [I.F=3.392].
6HIF1α-dependent upregulation of ATAD2 promotes proliferation and migration of stomach cancer cells in response to hypoxia. A Nayak, AD Roy, N Rout, SP Singh, A Bhattacharyya, A Roychowdhury, Biochem Biophys Res Commun. 2020 Mar 19;523(4):916-923. doi: 10.1016/j.bbrc.2019.12.130 [I.F=3.575].
7Mechanisms of interactions of the nucleotide cofactor with the RepA protein of plasmid RSF1010. Binding dynamics studied using the fluorescence stopped-flow method IE Andreeva, A Roychowdhury, MR Szymanski, MJ Jezewska, W. Bujalowski. Biochemistry. 2009 Nov 10; 48(44):10620-36. doi: 10.1021/bi900940q [I.F=3.162].
8Interactions of the Escherichia coli DnaB−DnaC Protein Complex with Nucleotide Cofactors. 1. Allosteric Conformational Transitions of the Complex. A Roychowdhury, MR Szymanski, MJ Jezewska, W Bujalowski, Biochemistry. 2009 Jul 28;48(29):6712-29. doi: 10.1021/bi900050x [I.F=3.162].
9Mechanism of NTP Hydrolysis by the Escherichia coli Primary Replicative Helicase DnaB Protein. 2. Nucleotide and Nucleic Acid Specificities. A Roychowdhury, MR Szymanski, MJ Jezewska, W Bujalowski. Biochemistry. 2009 Jul 28; 48(29):6730-46. doi: 10.1021/bi9000529 [I.F=3.162].
10Escherichia coli DnaB Helicase−DnaC Protein Complex: Allosteric Effects of the Nucleotides on the Nucleic Acid Binding and the Kinetic Mechanism of NTP hydrolysis. 3. A Roychowdhury, MR Szymanski, MJ Jezewska, W Bujalowski. Biochemistry. 2009 Jul 28; 48(29):6747-63. doi: 10.1021/bi9000535 [I.F=3.162].
11Accumulation of p-hydroxybenzoic acid in hairy roots of Daucus carota. D Sircar, A Roychowdhury, A Mitra J Plant Physiol. 2007 Oct; 164(10):1358-66. doi: 10.1016/j.jplph.2006.08.002 [I.F=3.549].
12Kinetic mechanisms of the nucleotide cofactor binding to the strong and weak nucleotide-binding site of the Escherichia coli PriA helicase. 2 AL Lucius, MJ Jezewska, A Roychowdhury, W Bujalowski. Biochemistry. 2006 Jun 13; 45(23):7217-36. doi: 10.1021/bi051827e [I.F=3.162].

Conferences (International)

1Roychowdhury A, Nayak A, Kumar S, Dixit A, BhattacharyyaA. Hypoxia-responsive and HIF1α-regulated AAA+ ATPase ATAD2 shows high oncogenic potential in stomach cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5680. https://doi.org/10.1158/1538-7445.AM2022-5680
2Nayak A, Kumar S, Bhattacharyya A, Dixit A, Roychowdhury A (2019). Cross-Cancer Study with a Special Emphasis on Stomach Cancer Reveals ATAD2 as Diagnostic and Prognostic Biomarker. Mol Biol Cell 30(26), pp. P-1150. https://doi.org/10.1091/mbc.E19-11-0617.
3Roychowdhury A, Nayak A, Bhattacharyya A. (2019). AAA+ ATPase ATAD2 signalling networks in gastric cancer. Biochem Mol Biol J Vol.5; doi: 10.21767/2471-8084-C3-029.
4Roychowdhury A, Robert J, Lee BH, Finley D. Characterization of the Non-catalytic Inhibitory Effect of Ubp6 on Proteasome Function. FASEB J. 27:553.23, 2013. https://doi.org/10.1096/fasebj.27.1_supplement.553.23
5Roychowdhury A, Jezewska MJ, Bujalowski W. Nucleotide Control of Replication Initiation: NTPase Mechanisms of E.coli DnaB-DnaC Complex. Biophysical J., vol. 96, issue 3, pp. 209a-209a, 2009.
6Roychowdhury A, Jezewska MJ, Bujalowski W. (2009). E.coli DnaB-DnaC Complex with Nucleotide Cofactors: An Allosteric Control of Recognition Process in DNA Replication. Special Issue: The 23rd Symposium of The Protein Society 2009: Abstract 235, Protein Science. vol. 18, issue S1, pp 137.
7Roychowdhury A, Jezewska MJ, Bujalowski W. (2008) Functional Studies of E.coli DnaB-DnaC Complex Indicates Its Role As a Part of Primosome. 2008 Biophysical Society Meeting Abstracts. Biophysical J., Supplement, vol. 94, issue 2, Abstract, pp. 675.
8Lucius, AL, Jezewska MJ, Roychowdhury A, Bujalowski W. (2006) Kinetic Mechanisms of the nucleotide Cofactor binding to the Strong and Weak Nucleotide-Binding Site of the Escherichia coli PriA Helicase. 2006 Biophysical Society Meeting Abstracts. Biophysical J., Supplement, vol. 90, Abstract, 981-Pos.
 

Academic Honors & Awards

  • Vanderbilt International Research Grant Award by Vanderbilt International Research Grants Program, Vanderbilt University, USA (2015).
  • Postdoctoral Research Fellowship, Harvard Medical School, Boston, MA (2010).
  • Irma Mendoza Scholarship Award, UTMB, Galveston, Texas (2009).
  • Biochemistry and Molecular Biology (BMB) Travel Award, UTMB, Galveston, Texas (2009).
  • The Protein Society Finn Wold Travel Award (2009).
  • The Robert A. Welch Award for Excellence in Graduate Research in Chemistry, UTMB, Galveston,Texas (2007).
  • Graduate Assistant Fellowship, UTMB, Galveston, Texas (2004).
  • Qualified GATE in Life Sciences (2002).
 

Research Scholar

  • Ph. D. students: 1 degree awarded; 3 continuing
  • M.Sc. students:  5 graduated; 2 continuing
 
 

Membership in scientific societies

  • Active Member, American Association for Cancer Research (AACR)
  • Life member, Indian Society of Translational Research (ISTR)
  • Life member, Society of Biological Chemists India (SBCI)

Book chapter

  • Mitra T., Mahapatra S.S., Mishra B., Panda V.K., Malhotra D., Roychowdhury A*, Kundu GC*. Hypoxia and its Biological Implications for Cancer Therapy [An invited book chapter for a Springer Nature book, under review].
  • Dutta M, Patra S, Saxena S, Roychowdhury, A*. Antimicrobials: Targets, Functions and Resistance. An invited book chapter of “Biomolecular Engineering Solutions for Renewable Specialty Chemicals: Microorganisms, Products, and Processes” (John Wiley & Sons, Inc.); pages 77-109; October 25, 2021.

Professional Experience

Postdoctoral Research Fellow at Prof. Daniel Finley's laboratory, Dept. of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA (2010-2013)

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