Dr. Soumendra RanaAssistant Professor
School of Basic Sciences

Research Interests

  • Structure Function Studies on Peptide or Protein binding G-protein Coupled Receptors
  • Rational Design of Peptides / Proteins as Therapeutics (Antimicrobial / Antiviral / Anti-inflammatory)
  • Chemical and Cellular Biology
  • Computational Biology and Bioinformatics
  • Protein-Protein Interactions
  • Drug Design and Discovery

Contact Details

  • 314, School of Basic Sciences
  • +91-674-7135154 (Office); +91-674-7135354 (Lab)
  • soumendra@iitbbs.ac.in

Other Profile Link(s)

Education

 Degree Discipline Year School
 Ph.D. Molecular Biophysics 2007 Indian Institute of Technology Bombay
 

Biosketch

 

Teaching

  • Chemistry (CY1L001)
  • Biosciences (CYA2001)
  • Introduction to Biosciences & Technology (ID2L001)
  • Receptor Pharmacology & Drug Discovery (CY7L020)
  • Chemical Biology of Receptors (CY7L016)
  • Structure Function of Biomolecules (CY7L019)
  • Biochemistry (CY7L001)
  • Computational Methods & Application (CY5L009)
  • Advanced Instrumentation Lab (CY5P004)
  • Organic Chemistry Lab (CY5P001)
  • Physical Methods in Inorganic Chemistry (CY7L006)
  • B. Tech Chemistry Lab (CY1P001)

Projects

  1. Rational Design, Synthesis, Structural and Biological Evaluations of Non-coded Amino acid (NCAA) Containing Peptides as Potential Anti-inflammatory and Antimicrobial Agents; (Under evaluation, SERB)

  2. Rational Design of Targeted Peptide Antibodies against hC5a, including Broad Spectrum Antiviral Peptides Potentially Targeting SARS-CoV-2  Spike Protein (Apr-Dec 2020); Sponsoring Agency-IIT Delhi, India.

  3. Structural Studies on the Interaction of hC5a with the N-terminus Peptides of C5aR and C5L2 Receptor (2017-2020); Sponsoring Agency-DST, New Delhi, India

  4. Structure-Function studies of Extra Cellular Loop 2 (ECL2) of C5aR and C5L2 receptors (2013-2015); Sponsoring Agency-IIT Bhubaneswar, India

Recent Publications (International Journals)

1Neutraligands of C5a and their Effect on the Function of the Complement Receptors. Rana et. al., 2022 (To be Submitted)
2Das, A.; Gupta, P.; Rana, S. C5aR2 Receptor: The Genomic Twin of the Flamboyant C5aR1. J. Cell. Biochem. 2022 (In Press)
3Behera, L. M.; Ghosh, M.; Rana, S. Deciphering the Conformational Landscape of Few Selected Aromatic Non-Coded Amino acids (NCAAs) for Applications in Rational Design of Peptide Therapeutics. Amino Acids, 2022, 54, 1183-1202.
4Das, A.; Behera, L. M.; Rana, S. "Interaction of Human C5a with the Major Peptide Fragments of C5aR1: Direct Evidence in Support of “Two-Site” Binding Paradigm". ACS Omega, 2021, 6(35): 22876-22887.
5Das, A.; Rana, S. "The Role of Human C5a as a Non-genomic Target in Corticosteroid Therapy for Management of severe COVID19". Comput. Biol. Chem. 2021, 92, 107482.
6Mishra, R.; Behera, L. M.; Rana, S. "Binding of Raloxifene to Human Complement fragment 5a (hC5a): A Perspective on Cytokine Storm and COVID19". J. Bimol. Struct. Dyn. 2020, 15, 1-13.
7Mishra, R.; Das, A.; Rana, S. "Resveratrol Binding to Human Complement fragment 5a (hC5a) may Modulate the C5aR Signaling". J. Bimol. Struct. Dyn. 2020, 17, 1-15.
8Mishra, R.; Rana, S. "A Rational Search for Discovering Potential Neutraligands of Human Complement fragment 5a (hC5a)." Bioorg. Med. Chem. 2019, 27, 115052
9Sahoo, A.; Mishra, R.; Rana, S. "The Model Structures of the Complement Component 5a Receptor (C5aR) Bound to the Native and Engineered hC5a." Sci. Rep. 2018, 8, 2955.
10Rana, S.; Sahoo, A.; Majhi, B. "Structural Complexes of Agonist, Inverse Agonist and Antagonist Bound C5a Receptor: Insights into Pharmacology and Signaling." Mol. BioSyst. 2016, 12, 1586-1599.
11Rana, S.; Sahoo, A.; Majhi, B. "Allosterism in human Complement Component 5a (hC5a): A Damper of C5a Receptor (C5aR) Signaling." J. Bimol. Struct. Dyn. 2015, 1-13.
12Rana, S.; Sahoo, A. "Model structures of inactive and peptide agonist bound C5aR: Insights into agonist binding, selectivity and activation." Biochem. Biophy. Rep. 2015, 1, 85-96.
13Kumar SS; Rana S; Nangia A. "Solid-state form screen of cardiosulfa and its analogues". Chem Asian J. 2013, 8, 1551-68.
14Akiri, K.; Cherukuvada, S.; Rana, S.; Nangia, A."Crystal Structures of Pyridine Sulfonamides and Sulfonic Acids." Cryst. Growth Des. 2012, 12, 4567-73.
15Rana, S.; Yang, L; Hassanian, S. M.; Rezaie A. R. "Determinants of the Specificity of Protease-activated Receptors-1 and 2 Signaling by Factor Xa and Thrombin." J. Cell. Biochem. 2012, 113, 977-84.
16Rana, S.; Baranski, T. J. "Third Extracellular Loop (EC3)-N terminus Interaction is Important for 7TM Receptor Function: Implication for an Activation 'Microswitch' Switch Region." J. Biol. Chem. 2010, 285, 31472-83.
17Rana, S.; Kundu, B.; Durani, S. "A Synthetic Cholinergic Receptor of Mixed-L, D Residues Exceptionally Small and Simple." Biopolymers 2007, 87, 231-243.
18Rana, S.; Kundu, B.; Durani, S. "A Double Catgrip Mixed L and D Mini Protein Only 20 Residues Long." Bioorg. Med. Chem. 2007, 15, 3874-3882.
19Joshi, S.; Rana, S.; Wangikar, P.; Durani, S. "Computational Design of Proteins Stereochemically Optimized in Size, Stability and Folding Speed". Biopolymers 2006, 83, 122-134. (Designed THBs were Featured on the Cover Page of Biopolymers).
20Rana, S.; Kundu, B.; Durani, S. "A Small Peptide Stereochemically Customized as a Globular Fold with a Molecular Cleft". Chemical Communications 2005, 11, 207-209. (Featured as Hot article by Royal Society of Chemistry and as news in Chem. Sci. and Chemistry World, Dec 26, 2004)
21Rana, S.; Kundu, B.; Durani, S. "Stereospecific Peptide Folds. A Rationally Designed Molecular Bracelet." Chemical Communications 2004, 21, 2462-2463.
 

Academic Honors & Awards

  • Member of the International Chemical Biology Society
  • Life Member of Society of Biological Chemists, India
  • Life Member of Indian Peptide Society
  • Life Member of American Peptide Society
 

Research Scholar

Ph.D: 2 graduated; 7 continuing
M.Sc: 7 graduated; 2 continuing
B.Tech: 1 completed
Winter Interns: 5 completed
Summer Interns: 1 completed
 

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Professional Experience

1: Washington University School of Medicine in Saint Louis, Missouri, USA, 2: Saint Louis University School of Medicine, Missouri, USA, 3: University of Arizona, Tucson, Arizona, USA

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