Photo of Tabrez Khan

Dr. Tabrez KhanAssistant Professor
School of Basic Sciences

Research Interests

Synthetic Method Development; Natural Product Synthesis; Heterocyclic Chemistry; Organocatalysis; Asymmetric Syntheses using Chiral Pool Approach

Brief Resume

Contact Details

  • Room No 220, 2nd Floor, SBS Building, Argul Campus
  • 0674 7135164
  • tabrez@iitbbs.ac.in

Other Profile Link(s)

Education

 Degree Discipline Year School
 Ph.D. Organic Chemistry 2009 University Of Mumbai
 DSK Postdoctoral Fellow Natural Products Synthesis 2010-2011 Indian Institute of Science Bangalore
 DSK Postdoctoral Fellow Natural Products Synthesis 2011-2012 Hyderabad Central University
 Fulbright-Nehru Postdoctoral Fellow Natural Products Synthesis 2012-2013 The Scripps Research Institute, California
 

Biosketch

 

Teaching

Concepts of Organic Synthesis (CY5L003); Organic chemistry Lab. (CY5P001); Organic Spectroscopy (CY5L028); Advanced Organic Chemistry (CY5L007);

 

Recent Publications (International Journals)

1A silica-gel accelerated [4+2] cycloaddition-based biomimetic approach towards the first total synthesis of magterpenoid C; Dileep Kumar, Virendra Kumar, Abdus Salam and Tabrez Khan, Tetrahedron Lett. 2019, 60, Article 151137
2Scalable Total Syntheses of some Natural and Unnatural Lamellarins: Application of a One-Pot Domino process for Regioselective Access to the Central 1,2,4-Trisubstituted Pyrrole Core; Virendra Kumar, Annapurna Awasthi, Abdus Salam and Tabrez Khan, J. Org. Chem. 2019, 84, 11596-11603.
3A Metal Free Domino Process for Regioselective Synthesis of 1,2,4-Trisubstituted Pyrroles: Application towards the Formal Synthesis of Ningalin B; Virendra Kumar, Annapurna Awasthi, Abhisek Metya and Tabrez Khan, J. Org. Chem. 2019, 84, 11581-11595.
4Total Syntheses of several Iridolactones and the Putative Structure of Noriridoid Scholarein A: An Intramolecular Pauson-Khand Reaction based One-stop Synthetic Solution; Abdus Salam, Sayan Ray, Md. Abu Zaid, Dileep Kumar and Tabrez Khan, Org. Biomol. Chem. 2019, 17, 6831-6842.
5A De Novo Approach for the Stereoselective Synthesis of Cyclopenta[c]pyranone Scaffold Present in Iridoids: Formal Syntheses of Isoboonein, Iridomyrmecin and Isoiridomyrmecin, Manvendra Singh Kaurav, Virendra Kumar, Dileep Kumar and Tabrez Khan, ChemistrySelect, 2018, 3, 5566-5570
6Synthetic studies en route to the first total synthesis of a naturally occurring quinone from Acorus gramineus, iso-merrilliaquinone, iso-magnoshininand 2-epi-3,4-dihydro magnoshinin; Dileep Kumar, Oindreela Das, Manvendra Singh Kaurav, Tabrez Khan, RSC Advances. 2017, 7, 36844-36851.
7“An Improved Synthesis of Natural Product Inspired Chromenopyrrolizines and Chromenoindolizines Scaffolds: Rapid Access to the Diverse Pyrrolizine Analogs of Aza-Medicarpin and Tetracyclic Isolamellarin Core through a General Base and Metal free Strategy” Tabrez Khan, Virendra Kumar, Oindreela Das, Bull. Chem. Soc. Jpn. 2016, 89, 1331.
8"Total Synthesis and Structural Revision of Antibiotic CJ-16,264" K. C. Nicolaou, Akshay A. Shah, Henry Korman, Tabrez Khan, Lei Shi, Wisuttaya Worawalai, Emmanuel A. Theodorakis, Angew.Chem. Int.Ed. 2015, 54,9203 –9208
9Model studies toward a synthesis of asperaculin A: exploration of iterative intramolecular Pauson–Khand reaction based strategies to access the dioxa[5.5.5.6]fenestrane framework"; Goverdhan Mehta, Tabrez Babu Khan, Tetrahedron Letters, 2012, 53, 4558-4561.
10"(1’S,6’S,8’S,9’R)-9’-Bromo-12’-oxaspiro-[1,3-dioxolane-2,4’-tricyclo[6.3.1.01,6]- dodecane]"; Goverdhan Mehta, Tabrez Babu Khan, Acta Crystallogr., Sect. E: Struct. Rep. Online, 2012, E68, o2411-o2412.
11"A biomimetic total synthesis of allomicrophyllone: protective Diels–Alder reaction as a stratagem"; Goverdhan Mehta, Tabrez Babu Khan, Tetrahedron Letters, 2010, 51, 6590-6593.
12"Total synthesis of the fungal metabolite (±)-acremine G: acceleration of a biomimetic Diels–Alder reaction on silica gel"; Goverdhan Mehta, Tabrez Babu Khan, Y.C. Sunil Kumar, Tetrahedron Letters, 2010, 51, 5116-5119.
13"Total syntheses of the fungal metabolites (±)-acremines A, B and I"; Goverdhan Mehta, Y.C. Sunil Kumar, Tabrez Babu Khan, Tetrahedron Letters, 2010, 51, 5112- 5115.
14"Anthracene-tethered aminomethyl oxadiazole chemosensor: a probe offering selective chromo- and fluorogenic signaling for targeting Cu(II)"; Sabir H. Mashraqui, Tabrez Khan, Mukesh Chandiramani, Rupesh Betkar and Kiran Poonia, Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2010, 67, 361-367.
15"Rhodamine–Pyridyl Probe: A Selective Optical Reporter for Biologically Important Zn2+, Sabir H. Mashraqui, Tabrez Khan, Subramanian Sundaram, Rupesh Betkar and Mukesh Chandiramani, Chemistry Letters, 2009, 38, 730-731.
16"Phenothiazine-pyridyl chalcone: A new easily accessible colorimetric and fluorimetric "on-off " dual sensing probe for Cu2+", Sabir H. Mashraqui, Tabrez Khan, Subramanian Sundaram, and Shailesh Ghadigaonkar, Tetrahedron Letters, 2008, 49, 3739-3743.
17"New PCT probes featuring N-phenylmonoaza-18-crown-6 and aryl/pyridyloxadiazoles: Optical Spectral Studies of Solvent effects and selected metal ions";Sabir H. Mashraqui, Subramanian Sundaram, Tabrez Khan, Shailesh Ghadigaonkar and Kirandevi Poonia, Journal of Inclusion Phenomenon & Macrocyclic Chemistry, 2008, 62, 81-90.
18"A new intramolecular charge transfer receptor as a selective ratiometric "off-on" sensor for Zn2+", Sabir H. Mashraqui, Tabrez Khan, Subramanian Sundaram, Rupesh Betkar and Mukesh Chandiramani, Tetrahedron Letters, 2007, 48, 8487- 8490.
19"Zn2+ selective luminescent "off-on" probes derived from diaryl oxadiazole and aza- 15-crown-5"; Sabir H. Mashraqui, Subramanian Sundaram, Tabrez Khan and A. C. Bhasikuttan, Tetrahedron, 2007, 63, 11093-11100.
20"Benzimidazole-Chalcone: A Selective Intramolecular Charge-transfer Probe for Biologically Important Zinc Ions", Sabir H. Mashraqui, Subramanian Sundaram and Tabrez Khan, Chemistry Letters, 2006, 35, 786-787.

Recent Publications (National Journals)

1"Aza-crown ether tethered with benzothiazole: Synthesis and optical spectral studies", Sabir H. Mashraqui, Vashi Dhaval, Subramanian Sundaram and Tabrez B. Khan, Indian Journal of Chemistry, 2006, 45 B, 815-819.

Conferences (International)

1Tabrez Khan, Virendra Kumar & Oindreela Das, "A Rapid Access to the Diverse Pyrrolizine Analogs of Aza-Medicarpin and Tetracyclic Isolamellarin Core through a General Base and Metal free Strategy" (ICOS-21), Dec 2017, IIT Bombay, India
2Tabrez Khan & Oindreela Das, "Synthetic Studies towards some natural product with potent cytotoxicity towards HCC cells" First International Conference on Nutraceuticals & Chronic Diseases (INCD-2016), Sept. 2016, Kerala, India
3Goverdhan Mehta & Tabrez Khan, “Biomimetically Inspired First Total Synthesis of Allomicrophyllone”, 6th Junior National Organic Symposium trust Conference (J- NOST), 2011, Hyderabad, India.
4Goverdhan Mehta, Sunil Kumar Y. C., Tabrez Khan, “Total Syntheses of Acremine A, B, I & G”, 5th Junior National Organic Symposium trust Conference (J-NOST), 2009, Kanpur, India.
 

Academic Honors & Awards

  • Fulbright-Nehru Postdoctoral fellowship from the United States-India Education Foundation (USIEF), New Delhi, India (2012-2013).
  • Dr. D. S. Kothari Postdoctoral fellowship from the University Grants Commission (UGC), New Delhi, India (2009-2012).
  • Best Poster Award at Trombay Symposium for Radiation and Photochemistry from the Department of Atomic Energy, Govt. of India (2008).
  • Best Talk Award at Ph.D Student Symposium from the Royal Society of Chemistry- West India Section (2007).
  • Junior & Senior Research Fellowship Award from the Council of Scientific & Industrial Research (CSIR), New Delhi, India (2004-2008).
  • Graduate Aptitude Test In Engineering (GATE) Award from the Indian Institute of Technology, India (2004).
  • Maharashtra State level Eligibility for Lectureship Award from the University Grants Commission (UGC), New Delhi, India (2003).
 

Research Scholar

Ph.D.: 01 (Awarded); 01 (Submitted); 03 (Pursuing); Project Fellows: 01; M. Sc.: 03 (Pursuing); 08 (Completed)
 

Research Experience

  •  Assistant Professor- School of Basic Sciences, IIT Bhubaneswar,  April 2014- Present
  • Research Investigator- Medicinal Chemistry at BBRC (Biocon-BMS R&D Centre, Syngene Intl. Ltd), Bangalore,  India, Sept. 2013- April 2014.  
  • Postdoctoral Researcher with Prof. K. C. Nicolaou at The Scripps Research Institute, CA, USA, 2012-2013.
  • Postdoctoral Researcher with Prof. Goverdhan Mehta at Hyderabad Central University, India, 2010-2012.  
  • Postdoctoral Researcher with Prof. Goverdhan Mehta at Indian Institute of Science, Bangalore, India, 2009-2010.
  • Research Associate at GlaxoSmithKline Pharmaceuticals, Maharashtra, India, 2008-2009.  
  • Doctoral Research at University of Mumbai with Prof. S. H. Mashraqui, Maharashtra, India, 2003-2008

 

Professional Experience

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